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- Title
Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation.
- Authors
Zhang, Jiexin; Chen, Xian; Rong, Guodong; Xu, Ting; Zhao, Hong; Chen, Dan; Wu, Lei; Huang, Peijun; Wang, Fang
- Abstract
Background: The main purpose of this study was to investigate the relationship among cytomegalovirus (CMV) viremia, peripheral immune cells alternations, and leukemia prognosis. Patients and methods: We studied 90 leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from 2008 to 2015. Their complete clinical laboratory data were collected until 1 year after transplantation. Results: All patients were serum CMV negative before allo-HSCT. After transplantation, the CMV reactivation group showed increased peripheral CD8+ T cells and decreased CD4+ T cells and B cells. However, CD8/CD4 ratio and B cells restored by control of CMV infection due to 2 months maximum course of ganciclovir treatment. CMV seropositivity was positively related to leukemia-free survival (LFS) of all recruited leukemia types. Conclusion: In summary, CMV drives immune cell post-transplantation fluctuation, which also favors LFS of leukemia partly resulted from CD8+ T cells.
- Subjects
HEMATOPOIETIC stem cell transplantation; LYMPHOCYTES; CYTOMEGALOVIRUSES; LEUKEMIA; B cells
- Publication
OncoTargets & Therapy, 2018, Vol 11, p5143
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S160178