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- Title
A Focused Scanning Vertical Beam for Charged Particle Irradiation of Living Cells with Single Counted Particles.
- Authors
Merchant, Michael J.; Jeynes, Jonathan C. G.; Grime, Geoffrey W.; Palitsin, Vladimir; Tullis, Iain D. W.; Barber, Paul R.; Vojnovic, Boris; Webb, Roger P.; Kirkby, Karen J.
- Abstract
The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem™ accelerator supply a range of ions from protons to calcium for this beamline and microscope endstation, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 μm and selectively target human fibroblasts with a <5 μm carbon beam, using γ-H2AX immunofluorescence to demonstrate which cell nuclei were irradiated. We discuss future commissioning steps necessary to achieve submicron targeting accuracy with this beamline.
- Subjects
IRRADIATION; IONIZING radiation; IMMUNOFLUORESCENCE; CELL nuclei; IONS
- Publication
Radiation Research, 2012, Vol 178, Issue 3, p182
- ISSN
0033-7587
- Publication type
Article
- DOI
10.1667/RR2847.1