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- Title
Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals.
- Authors
Karlsson, Ingrid; Tingstedt, Jeanette Linnea; Şahin, Gülşen Özkaya; Hansen, Mikkel; Szojka, Zsofia; Buggert, Marcus; Biague, Antonio; Silva, Zacharias Da; Månsson, Fredrik; Esbjörnsson, Joakim; Norrgren, Hans; Medstrand, Patrik; Fomsgaard, Anders; Jansson, Marianne; Group, Sweden-Guinea-Bissau Cohort Research; Sahin, Gülsen Özkaya; Da Silva, Zacharias; Sweden-Guinea-Bissau Cohort Research Group
- Abstract
Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.
- Subjects
ANTIBODY-dependent cell cytotoxicity; IMMUNOGLOBULINS; HIV; ANTIGEN-antibody reactions; COMPARATIVE studies; GLYCOPROTEINS; HIV infections; IMMUNITY; RESEARCH methodology; MEDICAL cooperation; PROTEINS; RESEARCH; T cells; VIRAL antibodies; EVALUATION research
- Publication
Journal of Infectious Diseases, 2019, Vol 219, Issue 11, p1749
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz001