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- Title
Rotavirus Vaccine Take in Infants Is Associated With Secretor Status.
- Authors
Armah, George E; Cortese, Margaret M; Dennis, Francis E; Yu, Ying; Morrow, Ardythe L; McNeal, Monica M; Lewis, Kristen D C; Awuni, Denis A; Armachie, Joseph; Parashar, Umesh D
- Abstract
Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2–3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2–8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.
- Subjects
ROTAVIRUSES; ROTAVIRUS vaccines; SALIVA; BLOOD group antigens; ABO blood group system; INFANTS; SEROCONVERSION
- Publication
Journal of Infectious Diseases, 2019, Vol 219, Issue 5, p746
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiy573