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- Title
Serological Evidence for the Circulation of Ebolaviruses in Pigs From Sierra Leone.
- Authors
Fischer, Kerstin; Jabaty, Juliet; Suluku, Roland; Strecker, Thomas; Groseth, Allison; Fehling, Sarah K; Balkema-Buschmann, Anne; Koroma, Bashiru; Schmidt, Kristina M; Atherstone, Christine; Weingartl, Hana M; Mettenleiter, Thomas C; Groschup, Martin H; Hoenen, Thomas; Diederich, Sandra
- Abstract
Many human ebolavirus outbreaks have been linked to contact with wildlife including nonhuman primates and bats, which are assumed to serve as host species. However, it is largely unknown to what extent other animal species, particularly livestock, are involved in the transmission cycle or act as additional hosts for filoviruses. Pigs were identified as a susceptible host for Reston virus with subsequent transmission to humans reported in the Philippines. To date, there is no evidence of natural Ebola virus (EBOV) infection in pigs, although pigs were shown to be susceptible to EBOV infection under experimental settings. To investigate the potential role of pigs in the ecology of EBOV, we analyzed 400 porcine serum samples from Sierra Leone for the presence of ebolavirus-specific antibodies. Three samples reacted with ebolavirus nucleoproteins but had no neutralizing antibodies. Our results (1) suggest the circulation of ebolaviruses in swine in Sierra Leone that are antigenically related but not identical to EBOV and (2) could represent undiscovered ebolaviruses with unknown pathogenic and/or zoonotic potential.
- Subjects
PHILIPPINES; SIERRA Leone; EBOLA virus; EPIDEMICS; NEUTRALIZATION tests; VIRAL transmission; NUCLEOPROTEINS; ANIMAL experimentation; ANIMAL populations; COMPARATIVE studies; EBOLA virus disease; IMMUNOGLOBULINS; RESEARCH methodology; MEDICAL cooperation; PROTEINS; RESEARCH; SERUM; SWINE; VIRAL antibodies; EVALUATION research
- Publication
Journal of Infectious Diseases, 2018, Vol 218, pS305
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy330