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- Title
Smoking cessation may present a positive impact on mandibular bone quality and periodontitis-related bone loss: a study in rats.
- Authors
César-Neto, João B.; Benatti, Bruno B.; Neto, Francisco Haiter; Sallum, Antonio W.; Sallum, Enilson A.; Nociti Jr., Francisco H.; César-Neto, João B; Nociti, Francisco H
- Abstract
<bold>Background: </bold>It has been previously shown that cigarette smoke inhalation (CSI) enhances bone loss in ligature-induced periodontitis. In this study, the hypothesis that the interruption of smoke exposure would reverse the impact of CSI on mandibular bone quality and periodontitis-related bone loss was tested. <bold>Methods: </bold>Fifty-three Wistar rats were randomly assigned to one of the following groups: group 1: control, N = 16; group 2: 83 days of CSI prior to ligature placement, N = 17; or group 3: 90 days of CSI before and 60 days after ligature placement, N = 20. Animals were sacrificed 60 days after ligature placement, the jaws removed and immediately radiographed for photodensitometry analysis. Bone loss was histometrically evaluated. <bold>Results: </bold>CSI did not affect unligated sites in either condition (P >0.05); however, smoke inhalation during the whole experimental period significantly enhanced bone loss in ligated teeth (P < 0.05). Moreover, similar levels of bone loss were observed for ligated teeth between the control and cessation groups (0.90 +/- 0.33 mm(2); 0.96 +/- 0.32 mm(2); 1.64 +/- 0.65 mm(2); groups 1, 2 and 3, respectively). Radiographically, continuous exposure to cigarette smoke promoted a significantly reduced bone density (1.74 +/- 0.38 aluminum equivalence [Al eq]; 1.74 +/- 0.14 Al eq; and 0.68 +/- 0.10 Al eq for groups 1, 2, and 3, respectively). <bold>Conclusions: </bold>Within the limits of the present investigation, it can be assumed that CSI may enhance bone loss in ligature-induced periodontitis, and negatively impact mandibular bone quality. Additionally, smoke exposure cessation seems to reverse its impact on mandibular bone, and, therefore, may be of clinical relevance.
- Subjects
CIGARETTE smoke; PERIODONTITIS; ETIOLOGY of diseases; LIGATURE (Surgery); LABORATORY rats; SMOKING
- Publication
Journal of Periodontology, 2005, Vol 76, Issue 4, p520
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1902/jop.2005.76.4.520