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- Title
The mucus-hypersecreting tumor of the pancreas. Development and extension visualized by three-dimensional computerized mapping.
- Authors
Furukawa, Tohru; Takahashi, Tohru; Kobari, Masao; Matsuno, Seiki; Furukawa, T; Takahashi, T; Kobari, M; Matsuno, S
- Abstract
<bold>Background: </bold>Mucus-hypersecreting tumor of the pancreas appears as dilated ducts and cystic spaces filled with mucus. To determine where such tumors arise and how they extend, computer-aided three-dimensional reconstruction was done of the ductal system. This also was used to visualize the spatial relationships among epithelial hyperplasia, dysplasia, and carcinoma in situ (CIS).<bold>Methods: </bold>Surgically removed pancreases were studied from 12 patients with mucus-hypersecreting tumors. The specimens were fixed in buffered formaldehyde solution 10%, embedded in paraffin and semiserially sectioned at 3 microns at an interval of 60 microns. The ductal contours were differentiated among ducts lined by ordinary epithelia, hyperplastic epithelia, dysplastic cells, or CIS and were inputted into a computer system that integrated a three-dimensional image of ducts in the display.<bold>Results and Conclusions: </bold>(1) The tumors arose in the main pancreatic duct or its subbranches, and the cysts corresponded to segments expanded by the superficial growth of tumor cells; (2) areas of CIS arose in zones of preceding dysplasia, suggesting a dysplasia-carcinoma sequence; and (3) dysplastic or cancerous cells often extended intraductally over the dilated segments of ducts.
- Publication
Cancer (0008543X), 1992, Vol 70, Issue 6, p1505
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920915)70:6<1505::AID-CNCR2820700611>3.0.CO;2-D