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- Title
Repeated Intravaginal Inoculation with Cell-Associated Simian Immunodeficiency Virus Results in Persistent Infection of Nonhuman Primates.
- Authors
Kaizu, Masahiko; Weiler, Andrea M.; Weisgrau, Kim L.; Vielhuber, Kathleen A.; May, Gemma; Piaskowski, Shari M.; Furlott, Jessica; Maness, Nicholas J.; Friedrich, Thomas C.; Loffredo, John T.; Usborne, Amy; Rakasz, Eva G.
- Abstract
The goal of the present study was to develop a nonhuman primate model of intravaginal human immunodeficiency virus (HIV) transmission with cell-associated virus. Reproductively mature, cycling cynomolgus macaques with or without chemically induced, transient ulcers of the lower female reproductive tract repeatedly received challenge with a variable amount of in vitro simian immunodeficiency virus mac239-infected peripheral blood mononuclear cells. Persistent viremia was established with surprisingly few infectious lymphocytes containing physiologically relevant quantities of cell-associated virus. This model will be indispensable for the testing of vaccines and topical agents that are aimed toward the prevention of heterosexual transmission of HIV.
- Subjects
HIV infections; INFECTIOUS disease transmission; CHEMOPREVENTION; VIRAL vaccines; KRA; PRIMATES
- Publication
Journal of Infectious Diseases, 2006, Vol 194, Issue 7, p912
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/507308