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- Title
Oculomotor function in amyotrophic lateral sclerosis: Evidence for frontal impairment.
- Authors
Shaunak, S.; Orrell, R. W.; O'Sullivan, E.; Hawken, M. B.; Lane, R. J. M.; Henderson, L.; Kennard, C.
- Abstract
Saccadic eye movements, fixation, and smooth pursuit were recorded in 17 subjects with amyotrophic lateral sclerosis (ALS) and 11 age-matched controls using a magnetic scleral search coil. Reflexive, remembered and antisaccades, and smooth pursuit at four target velocities were studied. Subjects with ALS showed significantly elevated error rates (distractibility) and latency in the antisaccade and remembered saccade paradigms but no abnormality of reflexive saccades. The frequency of small saccades that intruded on steady fixation (square-wave jerks) was also increased in ALS subjects. Peak velocity gain of smooth pursuit and performance on the Wisconsin Card Sort Test did not differ significantly between the two groups. These findings are consistent with prefrontal dysfunction in ALS and provide an independent source of support for the thesis that the pathology of this condition invades frontal cortex.
- Publication
Annals of Neurology, 1995, Vol 38, Issue 1, p38
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410380109