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- Title
Expression of Programmed Death Ligand 1 Is Associated with the Prognosis of Intrahepatic Cholangiocarcinoma.
- Authors
Dong, Zhitao; Liao, Boyi; Shen, Weifeng; Sui, Chengjun; Yang, Jiamei
- Abstract
<bold>Background: </bold>Programmed death ligand 1 (PD-L1) is expressed in many malignancies and plays a critical role in escape from immune surveillance through inhibition of its receptor programmed death 1. The role of PD-L1 in intrahepatic cholangiocarcinoma (ICC) and mechanisms of its regulation, however, remain largely unknown.<bold>Aims: </bold>To analyze the expression and prognostic significance of PD-L1 in ICC and to study the regulatory mechanisms of PD-L1.<bold>Methods: </bold>Samples were obtained from 125 patients diagnosed with ICC in the Eastern Hepatobiliary Surgery Hospital from January 2012 to January 2013. The records of each patient were analyzed to examine the relationship between PD-L1 and clinical data. In vitro experiments were performed to investigate the relationship between PD-L1 and the IL-6/mTOR signaling pathway and the feedback mechanism pathway of PD-L1.<bold>Results: </bold>Expression of PD-L1 is closely related to tumor vascular invasion, lymphatic metastasis and TNM staging. High PD-L1 expression is closely related to poor prognosis in ICC. Mechanically, IL-6 induces PD-L1 expression through mTOR signaling in ICC cells. In addition, PD-L1 has a negative feedback inhibition effect on AKT signaling.<bold>Conclusions: </bold>In summary, high PD-L1 expression was found to be associated with poor prognosis. The IL-6/mTOR pathway upregulates expression of PD-L1, thus promoting tumor invasion, and PD-L1 negatively inhibits the AKT pathway.
- Subjects
LYMPHATIC metastasis; BILIARY tract cancer; DEATH receptors; PROGNOSIS; LIVER cancer; INTERLEUKINS; BIOCHEMISTRY; BILE duct tumors; CHOLANGIOCARCINOMA; CANCER invasiveness; MULTIVARIATE analysis; WESTERN immunoblotting; CELLULAR signal transduction; TUMOR classification; PHENOMENOLOGY; TRANSFERASES; BILE ducts; CELL lines; POLYMERASE chain reaction; LOGISTIC regression analysis; LYMPHATIC abnormalities; PSYCHOTHERAPY
- Publication
Digestive Diseases & Sciences, 2020, Vol 65, Issue 2, p480
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-019-05787-0