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- Title
Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice.
- Authors
Park, Mi-Young; Ji, Geun; Sung, Mi-Kyung
- Abstract
Background: In ulcerative colitis (UC), reduction of inflammation may represent a key mechanism in UC therapy, and anti-inflammatory agents would be good candidates for preventing UC. Kaempferol, a natural flavonoid, is believed to have anti-inflammatory activities and has been shown to be potentially immune-modulatory. Aims: The aim of this study was to determine whether kaempferol alleviates the inflammatory responses of dextran sulfate sodium (DSS)-induced colitis in mice. Methods: Female C57BL/6J mice were divided into six groups: a negative control group, a DSS control group, and DSS + 0.1% or 0.3% kaempferol pre- or post-fed groups. At the end of the experimental period, clinical and biochemical markers were evaluated. Results: Plasma levels of NO and PGE were significantly decreased in both the 0.3% kaempferol pre- and post-fed groups. The plasma LTB level was profoundly decreased in all animals fed kaempferol. Colonic mucosa MPO activity was also suppressed in both the 0.3% kaempferol pre- or post-fed groups. TFF3 mRNA, a marker for goblet cell function, was up-regulated in kaempferol pre-fed animals. Conclusions: These results indicate that kaempferol is an effective anti-inflammatory agent that protects colonic mucosa from DSS-induced UC. Dietary kaempferol fed prior to colitis induction was more effective to suppress some of the colitis-associated markers.
- Subjects
DEXTRAN; SODIUM sulfate; COLITIS treatment; FLAVONOIDS; ANTI-inflammatory agents; BIOMARKERS; EXFOLIATIVE cytology; LABORATORY mice
- Publication
Digestive Diseases & Sciences, 2012, Vol 57, Issue 2, p355
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-011-1883-8