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- Title
Cell therapy for epilepsy using GABAergic neural progenitors.
- Authors
Anderson, Stewart A.; Baraban, Scott C.
- Abstract
Cell transplantation may repair neural circuits in the epileptic brain. Grafted cells should disperse, migrate, and functionally integrate. Generation of inhibitory interneurons with these abilities could be therapeutic in a condition of abnormal neuronal hyperexcitability, that is, epilepsy. This review discusses recent efforts to isolate and transplant interneuron precursor cells derived from the medial ganglionic eminence. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at ).
- Subjects
CELLULAR therapy; EPILEPSY; NEURAL circuitry; BRAIN diseases; SEIZURES (Medicine)
- Publication
Epilepsia (Series 4), 2010, Vol 51, p94
- ISSN
0013-9580
- Publication type
Article
- DOI
10.1111/j.1528-1167.2010.02880.x