We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Histone modification in psoriasis: Molecular mechanisms and potential therapeutic targets.
- Authors
Liu, Ruifeng; Zhang, Luyao; Zhang, Kaiming
- Abstract
Psoriasis is an immune‐mediated, inflammatory disease. Genetic and environmental elements are involved in the nosogenesis of this illness. Epigenetic inheritance serves as the connection between genetic and environmental factors. Histone modification, an epigenetic regulatory mechanism, is implicated in the development of numerous diseases. The basic function of histone modification is to regulate cellular functions by modifying gene expression. Modulation of histone modification, such as regulation of enzymes pertinent to histone modification, can be an alternative approach for treating some diseases, including psoriasis. Herein, we reviewed the regulatory mechanisms and biological effects of histone modifications and their roles in the pathogenesis of psoriasis. This paper reviewed the regulatory mechanisms and biological effects of histone modifications and their roles in the pathogenesis of psoriasis. It highlights the role of epigenetic inheritance and the potential of targeting histone modification as an alternative therapeutic approach for psoriasis and other‐related diseases.
- Subjects
HEREDITY; ENZYME regulation; DRUG target; CELL physiology; GENE expression
- Publication
Experimental Dermatology, 2024, Vol 33, Issue 8, p1
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.15151