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- Title
Impact of Phlebotomy on Quality of Life in Low-Risk Polycythemia Vera.
- Authors
Visweshwar, Nathan; Fletcher, Bradley; Jaglal, Michael; Laber, Damian A.; Patel, Ankita; Eatrides, Jennifer; Rathnakumar, Geetha Rajasekharan; Iyer, Keshav Visweswaran; Ayala, Irmel; Manoharan, Arumugam
- Abstract
Polycythemia vera is an indolent myeloproliferative disorder that predisposes patients to venous and arterial thrombosis and can transform into myelofibrosis and acute myeloid leukemia. Consistent phlebotomy prevents life-threatening cerebrovascular and coronary artery disease and prolongs survival in low-risk polycythemia vera (patients under 60 years without thrombosis). However, despite its effectiveness in preventing serious complications, phlebotomy does not necessarily enhance the quality of life (QoL). This review assesses QoL issues associated with low-risk PV, explores alternative management strategies such as erythrocytapheresis, and discusses the roles of hydroxyurea, peginterferon, ruxolitinib, and other novel agents in potentially improving disease management and patient outcomes.
- Subjects
POLYCYTHEMIA vera; ACUTE myeloid leukemia; MYELOPROLIFERATIVE neoplasms; CORONARY artery disease; VENOUS thrombosis
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 16, p4952
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13164952