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- Title
Effect of Vitamin D and Skeletal Muscle Mass on Prognosis of Patients with Diffuse Large B-Cell Lymphoma.
- Authors
Nakamura, Nobuhiko; Kanemura, Nobuhiro; Matsumoto, Takuro; Nakamura, Hiroshi; Shibata, Yuhei; Yamaguchi, Kimihiro; Kitagawa, Junichi; Ikoma, Yoshikazu; Suzaki, Tomomi; Kaneda, Yuto; Ninomiya, Soranobu; Takada, Eri; Hara, Takeshi; Tsurumi, Hisashi; Shimizu, Masahito
- Abstract
This study investigated the prognostic impact of vitamin D deficiency and reduced skeletal muscle mass in diffuse large B-cell lymphoma (DLBCL) patients. A retrospective analysis of 186 newly diagnosed DLBCL patients from 2012 to 2022 was conducted, measuring serum 25-hydroxyvitamin D [25(OH)D] levels and the skeletal muscle index (SMI). Decreased vitamin D levels were linked to more severe DLBCL disease, with a median 25(OH)D concentration of 13 (4.0–27) ng/mL. Males in the group with a low SMI had a considerably lower 25(OH)D concentration. The optimal threshold of 25(OH)D levels for overall survival (OS) was 9.6 ng/mL, with lower values associated with a higher likelihood of recurrence and mortality. Multivariable analysis showed hazard ratios for OS of 1.4 [95% CI 0.77–2.5] for a low SMI and 3.2 [95% CI 1.8–5.8] for low 25(OH)D concentration. The combination of a low SMI and low vitamin D concentration resulted in the worst prognosis. Thus, low levels of vitamin D associated with disease progression significantly impact DLBCL prognosis, which can be further stratified by the SMI, providing valuable insights for patient management and potential therapeutic interventions.
- Subjects
VITAMIN D deficiency; MORTALITY; SKELETAL muscle; CANCER relapse; RECEIVER operating characteristic curves; KRUSKAL-Wallis Test; FISHER exact test; RETROSPECTIVE studies; MULTIVARIATE analysis; MANN Whitney U Test; CHI-squared test; DESCRIPTIVE statistics; KAPLAN-Meier estimator; LOG-rank test; MEDICAL records; ACQUISITION of data; CANCER patient psychology; CONFIDENCE intervals; PROGRESSION-free survival; DATA analysis software; B cell lymphoma; VITAMIN D; OVERALL survival; DISEASE progression; PROPORTIONAL hazards models; SARCOPENIA
- Publication
Nutrients, 2024, Vol 16, Issue 16, p2653
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16162653