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- Title
The Role of Mitogen-Activated Protein Kinases and Their Relationship with NF-κB and PPARγ in Indomethacin-Induced Apoptosis of Colon Cancer Cells.
- Authors
KIM, TAE IL; JIN, SOO HYUN; KANG, EUN HYE; SHIN, SUNG KWAN; CHOI, KANG YELL; KIM, WON HO
- Abstract
A bstract: We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator-activated receptor γ (PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 973, Issue 1, p241
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb04641.x