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- Title
The Role of the Medullary Lateral Tegmental Field in the Generation and Baroreceptor Reflex Control of Sympathetic Nerve Discharge in the Cat.
- Authors
BARMAN, SUSAN M.; ORER, HAKAN S.; GEBBER, GERARD L.
- Abstract
A bstract: Data from experiments with single neuron recordings as well as central microinjections of N-methyl-d-aspartate (NMDA) and non-NMDA excitatory amino receptor antagonists that have led to a model of central sympathetic pathways that includes synaptic relays in the medullary lateral tegmental field (LTF) of the cat are summarized. Evidence is presented that (1) the LTF contains a population of tonically active sympathoexcitatory neurons that drive rostral ventrolateral medullary neurons, (2) blockade of non-NMDA receptors in the LTF significantly reduces basal levels of sympathetic nerve discharge (SND) and mean arterial pressure in baroreceptor-denervated cats, and (3) blockade of NMDA-mediated neurotransmission in the LTF prevents baroreceptor reflex control of SND. Thus, LTF neurons play an important role in the generation and baroreceptor reflex control of SND in the cat.
- Publication
Annals of the New York Academy of Sciences, 2001, Vol 940, Issue 1, p270
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2001.tb03683.x