We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Small Heat Shock Proteins and Protection against Injury.
- Authors
DILLMANN, WOLFGANG H.
- Abstract
A bstract: The small heat shock proteins αB crystallin and HSP27 exert a protective effect in response to simulated ischemia. A model is proposed whereby proteins not in their final folding state bind to the outside of the large oligomeric small heat shock protein complexes thus finding a safe haven during ischemia. After the ischemia is resolved, these proteins may be released and, with the help of HSP70, are shuttled to a productive refolding pathway resulting in proteins in their final folding state, which can assume their normal activity in cells recovered from ischemic injury.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 874, Issue 1, p66
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb09225.x