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- Title
Lichen amyloidosus: a study of clinical, histopathologic and immunofluorescence findings in 30 cases.
- Authors
Salim, T.; Shenoi, S. D.; Balachandran, C.; Rai Mehta, Vandana; Mehta, Vandana Rai
- Abstract
<bold>Background: </bold>Lichen amyloidosus (LA) is a primary localized cutaneous amyloidosis characterized clinically by discrete hyperkeratotic hyperpigmented papules and histologically by deposition of amyloid material in previously normal skin without any evidence of visceral involvement.<bold>Aims and Objectives: </bold>The aim of this work was to study the etiology, clinical features, histopathology and direct immunofluorescence findings in LA.<bold>Methods: </bold>A prospective study of 30 patients with clinical, histological and immunofluorescence findings suggestive of LA was undertaken. After a detailed history and clinical examination, two punch biopsies for histopathology and immunofluorescence were taken.<bold>Results: </bold>Of the 30 patients, 19 (63.3%) were males and 11 (36.7%) were females with duration of LA ranging from 6-20 months. Pruritus was the presenting symptom in 27 (90%) patients. Shin was involved in 26 (86.7%) followed by arms in three (10%) and back in one (3.3%). Seventeen patients (56%) had used scrubs for more than 2 years. Histopathology, direct immunofluorescence and Congo red staining detected amyloid in all cases.<bold>Conclusions: </bold>LA commonly presents over the shins as pruritic discrete hyperpigmented papules. Familial predisposition and friction may have a pathogenic role. Histopathological examination is very useful in the detection of amyloid which may be supplemented with direct immunofluorescence and Congo red staining.
- Subjects
LICHENS; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; AMYLOIDOSIS; BIOPSY; PATIENTS
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2005, Vol 71, Issue 3, p166
- ISSN
0378-6323
- Publication type
journal article