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- Title
Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells.
- Authors
Liu, Xiaoyang; Abe-Kanoh, Naomi; Liu, Yujia; Zhu, Beiwei; Munemasa, Shintaro; Nakamura, Toshiyuki; Murata, Yoshiyuki; Nakamura, Yoshimasa
- Abstract
The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.
- Subjects
PHOSPHATIDYLINOSITOL 3-kinases; ISOTHIOCYANATES; CANCER cells
- Publication
Bioscience, Biotechnology & Biochemistry, 2017, Vol 81, Issue 11, p2212
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2017.1374830