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- Title
Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening.
- Authors
Rohner, Eliane; McGuire, F. Hunter; Liu, Yutong; Li, Quefeng; Miele, Kate; Desai, Samveg A.; Schmitt, John W.; Knittel, Andrea; Nelson, Julie A.E.; Edelman, Claire; Sivaraman, Vijay; Baker, Anna; Romocki, LaHoma S.; Rahangdale, Lisa; Smith, Jennifer S.
- Abstract
Background: We compared women's acceptability of urine and cervico-vaginal sample self-collection for high-risk (oncogenic) human papillomavirus (hrHPV) testing and assessed whether acceptability varied across racial/ethnic groups. Methods: As part of a test accuracy study of urine-based hrHPV testing, we recruited a convenience sample of women 25–65 years of age at two colposcopy clinics in North Carolina between November 2016 and January 2019. After self-collection of urine and cervico-vaginal samples, women completed a questionnaire on the acceptability of the sample collection methods. We coded open-ended questions inductively. All results are presented stratified by racial/ethnic group. Results: We included 410 women (119 Hispanic, 115 non-Hispanic Black, 154 non-Hispanic White, and 22 women with other racial identities). Most women (79%, 95% confidence interval [CI] = 76%–83%) had positive feelings about urine-based hrHPV testing. Women generally preferred urine (78%, 95% CI = 74%–82%) over cervico-vaginal self-collection (18%, 95% CI = 14%–22%), but the degree differed by racial/ethnic group, increasing from 75% in non-Hispanic Black to 82% in Hispanic women (p = 0.011). Most women reported at least one positive aspect of urine (89%) and cervico-vaginal self-collection (85%) for hrHPV testing with the most common positive aspect being easy sample collection, although 16% of women were concerned about performing the cervico-vaginal self-collection correctly. Conclusions: Self-collection for hrHPV-based cervical cancer screening is highly acceptable to women across different racial/ethnic groups in the United States, and most women in our study would be more likely to attend future cervical cancer screening appointments if screening were urine based. Urine-based hrHPV testing is a promising approach to improve cervical cancer screening coverage.
- Subjects
NORTH Carolina; UNITED States; COLLECTION &; preservation of biological specimens; BLACK people; COLPOSCOPY; CONFIDENCE intervals; EMOTIONS; ETHNIC groups; HISPANIC Americans; PAP test; PAPILLOMAVIRUSES; QUESTIONNAIRES; RACE; STATISTICAL sampling; URINALYSIS; WHITE people; PSYCHOLOGY of women; CERVIX uteri tumors; POSITIVE psychology; HUMAN research subjects; PATIENT selection; PATIENTS' attitudes; SELF diagnosis
- Publication
Journal of Women's Health (15409996), 2020, Vol 29, Issue 7, p971
- ISSN
1540-9996
- Publication type
Article
- DOI
10.1089/jwh.2019.8132