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- Title
Mitochondria‐Targeting Plasmonic Spiky Nanorods Increase the Elimination of Aging Cells in Vivo.
- Authors
Lu, Meiru; Qu, Aihua; Li, Si; Sun, Maozhong; Xu, Liguang; Kuang, Hua; Xu, Chuanlai
- Abstract
Cellular senescence is stress‐induced, irreversible growth arrest, and is thought to impair tissue function. The clearance of senescent cells can delay the features of senescence. Herein, we report the development of plasmonic core–shell spiky nanorods (CSNRs) surface‐modified with an anti‐beta‐2‐microglobulin (aB2MG) antibody and triphenylphosphonium (TPP), to target the mitochondria in senescent cells. aB2MG‐TPP@CSNRs irradiated with near‐infrared (NIR) light selectively caused mitochondrial damage and apoptosis of senescent cells with relatively low NIR light power, and the ability of CSNRs to activate and amplify the immune response in vitro and in vivo was discovered. The photo‐induced generation of reactive oxygen species (ROS) resulted in senescent‐cell apoptosis and immune adjuvant effect by CSNRs accelerated the clearance of senescent cells in mice. This study opens the way for the use of precisely regulated plasmonic nanostructures for immune adjuvant and photo‐induced apoptosis for age‐related senescence.
- Subjects
CELLULAR aging; NANORODS; REACTIVE oxygen species; IMMUNE response; APOPTOSIS
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 22, p8776
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202002576