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- Title
Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification.
- Authors
Russell, M. Grace; Jamison, Timothy F.
- Abstract
Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h−1.
- Subjects
LINEZOLID; ANTIBACTERIAL agents; CHEMICAL amplification; SOLVENTS; INTERMEDIATES (Chemistry)
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 23, p7760
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201901814