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- Title
N-Linked Glycans of Chloroviruses Sharing a Core Architecture without Precedent.
- Authors
De Castro, Cristina; Speciale, Immacolata; Duncan, Garry; Dunigan, David D.; Agarkova, Irina; Lanzetta, Rosa; Sturiale, Luisa; Palmigiano, Angelo; Garozzo, Domenico; Molinaro, Antonio; Tonetti, Michela; Van Etten, James L.
- Abstract
N-glycosylation is a fundamental modification of proteins and exists in the three domains of life and in some viruses, including the chloroviruses, for which a new type of core N-glycan is herein described. This N-glycan core structure, common to all chloroviruses, is a pentasaccharide with a b-glucose linked to an asparagine residue which is not located in the typical sequon N-X-T/S. The glucose is linked to a terminal xylose unit and a hyperbranched fucose, which is in turn substituted with a terminal galactose and a second xylose residue. The third position of the fucose unit is always linked to a rhamnose, which is a semiconserved element because its absolute configuration is virus-dependent. Additional decorations occur on this core N-glycan and represent a molecular signature for each chlorovirus.
- Subjects
GLYCAN structure; PROTEINS; GALACTOSE; RHAMNOSE; ASPARAGINE synthetase
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 2, p664
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201509150