We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Assessing the impact of chemotherapy-induced peripheral neurotoxicity on the quality of life of cancer patients: the introduction of a new measure.
- Authors
Driessen CM; de Kleine-Bolt KM; Vingerhoets AJ; Mols F; Vreugdenhil G; Driessen, C M L; de Kleine-Bolt, K M E; Vingerhoets, A J J M; Mols, F; Vreugdenhil, G
- Abstract
<bold>Purpose: </bold>To investigate the impact of chemotherapy-induced neurotoxicity on daily activities and quality of life (QoL) of cancer patients.<bold>Methods: </bold>QoL of all patients visiting the oncological outpatient ward of the Maxima Medical Centre in the Netherlands from October 2006 until March 2007 treated with taxanes, vinca-alkaloids and/or platinum compounds (n = 88) was compared with the QoL of patients that did not receive these treatments yet (n = 43). Patient-reported neuropathy symptoms were evaluated with the newly developed Chemotherapy Induced Neurotoxicity Questionnaire (CINQ) and the Functional Assessment of Cancer Therapy/Gynaecologic Oncology Group/Neurotoxicity (FACT/GOG-Ntx) questionnaire.<bold>Results: </bold>Patients treated with chemotherapy reported significantly more complaints of neuropathy (p < 0.001) and more paresthesias and dysesthesias in the upper (p < 0.001; p < 0.01) and lower extremities (p < 0.001) compared to those not treated with chemotherapy. They additionally experienced problems with fine motor function (e.g., getting (un)dressed, writing, and picking up small objects). Moreover, cold-induced paresthesias were frequently reported. Overall, patients indicated that their neuropathy had a negative effect on QoL.<bold>Conclusions: </bold>The newly developed CINQ and the FACT/GOG-Ntx results suggest a considerable negative impact of patient-reported neuropathy symptoms on daily activities and QoL in cancer patients treated with chemotherapy. However, further validation of the CINQ is needed.
- Publication
Supportive Care in Cancer, 2012, Vol 20, Issue 4, p877
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-011-1336-0