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- Title
Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
- Authors
Janssen, S.; Osbak, K.; Holman, R.; Hermans, S.; Moekotte, A.; Knap, M.; Rossatanga, E.; Massinga-Loembe, M.; Alabi, A.; Adegnika, A.; Meenken, C.; Vugt, M.; Kremsner, P.; Meintjes, G.; van der Poll, T.; Grobusch, M.
- Abstract
There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB ( n = 20) was associated with developing other forms of IRIS ( p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.
- Subjects
GABON; CENTRAL Africa; ANTIRETROVIRAL agents; IMMUNE reconstitution inflammatory syndrome; CUTANEOUS manifestations of general diseases; HIV-positive persons; LONGITUDINAL method; OPPORTUNISTIC infections; TIME; TUBERCULOSIS; DIAGNOSIS
- Publication
Infection, 2017, Vol 45, Issue 5, p669
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-017-1000-9