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- Title
Trimethoprim-sulfamethoxazole therapy for patients with carbapenemase-producing Klebsiella pneumoniae infections: retrospective single-center case series.
- Authors
Murri, Rita; Fiori, Barbara; Spanu, Teresa; Mastrorosa, Ilaria; Giovannenze, Francesca; Taccari, Francesco; Palazzolo, Claudia; Scoppettuolo, Giancarlo; Ventura, Giulio; Sanguinetti, Maurizio; Cauda, Roberto; Fantoni, Massimo
- Abstract
Objective: The objective of the study was to evaluate the efficacy and tolerability of trimethoprim-sulfamethoxazole (also known as co-trimoxazole, TMPS) to treat Klebsiella pneumoniae (Kp)- K. pneumoniae carbapenemase (KPC) infections. Methods: Clinical data of patients with a TMPS-susceptible Kp-KPC infection were collected as a case series. Results: We report clinical outcomes and tolerability for 14 patients infected by Kp-KPC strains susceptible to TMPS, including three bloodstream infections. In ten cases (71.4%), TMPS was administered as monotherapy. In all but one case, Kp-KPC infection was cured. In the remaining patient, therapy was discontinued because of an adverse event. Conclusions: The use of TMPS to treat TMPS-susceptible Kp-KPC infections seems promising.
- Subjects
TRIMETHOPRIM; SULFAMETHOXAZOLE; TREATMENT effectiveness; BACTERIAL proteins; COMBINATION drug therapy; DRUG side effects; RETROSPECTIVE studies; KLEBSIELLA infections; THERAPEUTICS
- Publication
Infection, 2017, Vol 45, Issue 2, p209
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-016-0968-x