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- Title
Dengue virus identification by transmission electron microscopy and molecular methods in fatal dengue hemorrhagic fever.
- Authors
Limonta, D.; Falcón, V.; Torres, G.; Capó, V.; Menéndez, I.; Rosario, D.; Castellanos, Y.; Alvarez, M.; Rodríguez-Roche, R.; Rosa, M.; Pavón, A.; López, L.; González, K.; Guillén, G.; Diaz, J.; Guzmán, M.
- Abstract
Dengue virus is the most significant virus transmitted by arthropods worldwide and may cause a potentially fatal systemic disease named dengue hemorrhagic fever. In this work, dengue virus serotype 4 was detected in the tissues of one fatal dengue hemorrhagic fever case using electron immunomicroscopy and molecular methods. This is the first report of dengue virus polypeptides findings by electron immunomicroscopy in human samples. In addition, not-previously-documented virus-like particles visualized in spleen, hepatic, brain, and pulmonary tissues from a dengue case are discussed.
- Subjects
DENGUE hemorrhagic fever; CYTOCHEMISTRY; DISEASE complications; ELECTRON microscopy; MOLECULAR diagnosis; POLYMERASE chain reaction; TREATMENT effectiveness; DIAGNOSIS
- Publication
Infection, 2012, Vol 40, Issue 6, p689
- ISSN
0300-8126
- Publication type
Report
- DOI
10.1007/s15010-012-0260-7