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- Title
Unrequested information from routine diagnostic chest CT predicts future cardiovascular events.
- Authors
Jacobs PC; Gondrie MJ; Mali WP; Oen AL; Prokop M; Grobbee DE; van der Graaf Y; Jacobs, Peter C; Gondrie, Martijn J; Mali, Willem P; Oen, Ayke L; Prokop, Mathias; Grobbee, Diederick E; van der Graaf, Yolanda
- Abstract
<bold>Objectives: </bold>An increase in the number of CT investigations will likely result in a an increase in unrequested information. Clinical relevance of these findings is unknown. This is the first follow-up study to investigate the prognostic relevance of subclinical coronary (CAC) and aortic calcification (TAC) as contained in routine diagnostic chest CT in a clinical care population.<bold>Methods: </bold>The follow-up of 10,410 subjects (>40 years) from a multicentre, clinical care-based cohort of patients included 240 fatal to 275 non-fatal cardiovascular disease (CVD) events (mean follow-up 17.8 months). Patients with a history of CVD were excluded. Coronary (0-12) and aortic calcification (0-8) were semi-quantitatively scored. We used Cox proportional-hazard models to compute hazard ratios to predict CVD events.<bold>Results: </bold>CAC and TAC were significantly and independently predictive of CVD events. Compared with subjects with no calcium, the adjusted risk of a CVD event was 3.7 times higher (95% CI, 2.7-5.2) among patients with severe coronary calcification (CAC score ≥6) and 2.7 times higher (95% CI, 2.0-3.7) among patients with severe aortic calcification (TAC score ≥5).<bold>Conclusions: </bold>Subclinical vascular calcification on CT is a strong predictor of incident CVD events in a routine clinical care population.
- Publication
European Radiology, 2011, Vol 21, Issue 8, p1577
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2112-8