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- Title
Comparison of Iodine-125 seeds implantation and afterloading radiotherapy in murine models of human cervical cancer.
- Authors
Li, Hai-xia; Zhao, Jing; Shen, Keng; Yang, Jia-xin; Zhang, Fu-quan; Chen, Jie
- Abstract
Objective: To compare the efficacies and side effects of Iodine-125 (I) seeds implantation with afterloading radiotherapy on tumor xenografts derived from Hela cells. Methods: Mice bearing Hela cells were randomly divided into three groups: two therapeutic groups receiving four I seeds implantation and afterloading therapy, respectively, and the one control group without any intervention. Comparisons were evaluated in aspects of curative efficacies (tumor volume, tumor inhibition rate and metastasis) and side effects (body weight, ovarian endocrine functions, skin lesion surrounding the tumor). Results: The xenografts tumor volume of therapeutic groups were significantly smaller than that of controls( p < 0.05),both of the I seeds implantation and afterloading therapy showed excellent tumor inhibition rate. Furthermore, I seeds implantation had milder side effects on skin, weight loss, ovarian endocrine functions. Conclusions: I seed implantation may be an alternative minimally invasive therapy for cervical cancer.
- Subjects
HEALTH outcome assessment; CERVICAL cancer treatment; CERVIX uteri; CANCER in women; LABORATORY mice; THERAPEUTIC use of iodine; RADIOISOTOPE brachytherapy
- Publication
Archives of Gynecology & Obstetrics, 2014, Vol 289, Issue 5, p1101
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-013-3107-2