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- Title
Oxidative Stress in Benign Prostatic Hyperplasia: A Systematic Review.
- Authors
Minciullo, Paola Lucia; Inferrera, antonino; Navarra, Michele; Calapai, Gioacchino; Magno, Carlo; Gangemi, Sebastiano
- Abstract
Background: Several parameters including inflammatory mediators, hormones, dietary factors, inflammatory genes, and oxidative stress (OS) have been considered to play a role in the development of benign prostatic hyperplasia (BPH). Prostate tissue damage and OS may lead to compensatory cellular proliferation with resulting hyperplastic growth. Methods: We searched MEDLINE for articles in English published up to March 2014 using the key words 'oxidative stress', 'antioxidants' and 'benign prostatic hyperplasia'. Results: Prostatic inflammation can cause the generation of free radicals. The extent of oxidative damage can be exacerbated by a decreased efficiency of antioxidant defense mechanisms. The balance between OS and the antioxidant component also has a role in developing prostate disease. Several works show the role of oxidant products and of depletion of antioxidant substances in BPH patients. It is accepted that free radicals play a role in carcinogenesis and that BPH should be considered a premalignant condition which may evolve into prostate cancer. High OS parameters and low antioxidant activity are more prominent in prostate cancer patients compared with BPH and controls. Conclusions: Further studies are needed to clarify the potential role of antioxidants in BPH also in view of preventing the progression to prostate cancer. © 2014 S. Karger AG, Basel
- Subjects
BENIGN prostatic hyperplasia; OXIDATIVE stress; INFLAMMATORY mediators; CELL proliferation; MEDLINE; ANTIOXIDANTS; SYSTEMATIC reviews
- Publication
Urologia Internationalis, 2015, Vol 94, Issue 3, p249
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000366210