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- Title
Failure of a daily haemofiltration programme using a highly permeable membrane to return β2-microglobulin concentrations to normal in haemodialysis patients.
- Authors
Canaud, B.; Assounga, A.; Kerr, P.; Aznar, R.; Mion, C.
- Abstract
In an attempt to return to normal serum β-microglobulin levels in a group of seven ESRD patients, a programme of daily HF with highly permeable AN69 membranes was undertaken. Pre-HF β-M serum levels stabilized after 4 days at 20 mg/1,only 40% lower than the initial concentration. A total of 985±20 mg β-M was removed over theweek. The β-M release rate averaged 97 μg/min witha broad range of values (63–128 μg/min). β-M release peaked at 602 μg/min 1 h after the end of the HF session before returning to baseline by 12 h post-HF. We conclude that a return to normal blood β-M concentrations in ESRD patients seems quite unrealistic despite a highly intensive extracorporeal therapy. Therefore other therapeutic alternatives have to be designed to prevent or cure β-M amyloidosis.
- Publication
Nephrology Dialysis Transplantation, 1992, Vol 7, Issue 9, p924
- ISSN
0931-0509
- Publication type
Article