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- Title
In-vitro activity of Sch 29482—a new penem antibiotic.
- Authors
Muench, R. L.; Mayhew, A. L.; Hindler, J. A.; Hewitt, W. L.; Young, L. S.
- Abstract
The in-vitro activity of Sch 29482 (SCH) against 906 aerobic Gram-negative bacilli was compared simultaneously with ampicillin, cephalothin, amikacin, and trimethoprim/suiphamethoxazole. The in-vitro activity of SCH against 1251 aerobic Gram-positive cocci was compared simultaneously with ampicillin, cephalothin, penicillin G, oxacillin and erythromycin. All organisms were clinical isolates and were tested by the ICS-WHO agar dilution method. On a weight basis, SCH was more active than ampicillin and cephalothin and was as active as amikacin against Enterobacteriaceae; more than 98% of the cultures were inhibited by 8 mg/l or less. Of 45 aminoglycoside-resistant Enterobacteriaceae, 80% were inhibited by 8 mg/l or less. SCH was active against Acinetobacter sp. but did not inhibit any strains of Pseudomonas spp. Against Staphylococcus aureus SCH was more active than all the other agents tested with 9l% of the strains inhibited by 0.5 mg/l or less. The activity of SCH was superior to that of ampicillin and erythromycin against coagulase negative staphylococci with 92% inhibited by 8 mg/l or less. Cephalothin was more active than SCH against coagulase-negative staphylococci. The activity of SCH against enterococci was not as good as that of ampicillin and penicillin. Of the 56 strains of other Gram-positive cocci tested, which included viridans group streptococci, group D streptococci, Streptococus pneumoniae and group B streptococci, all were inhibited by 8 mg/l.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1982, Vol 9, Issue suppl_C, p71
- ISSN
0305-7453
- Publication type
Article