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- Title
Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats.
- Authors
Nesterova, Natalia I.; Shcheblykina, Olesya V.; Kolesnichenko, Pavel D.; Nesterov, Arkady V.; Shcheblykin, Dmitry V.; Popova, Irina A.; Yakovlev, Dmitry V.
- Abstract
Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% - in the Mexidol- and Ethoxidol-treated groups, and 20% - in LKhT 3-17-treated group). Within the first day after the surgery, all rats with stroke had severe neurological disorders. However, by the 3rd day, the Ethoxidol- and LKhT 3-17-treated rats had a lower neurological deficit. By Day 14, all groups of animals treated with the test substances had a lower severity of post-stroke disorders than those in the control group, which was evident as a 1.5-time lower McGraw Stroke Index score. LKhT 3-17 substance showed the most pronounced neuroprotective effect. Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disordersa more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes.
- Subjects
TAURINE; HYDROXYPYRIDINES; HEMORRHAGE; VASCULAR diseases; ESSENTIAL hypertension; BLOOD flow
- Publication
Research Results in Pharmacology, 2019, Vol 5, Issue 3, p87
- ISSN
2658-381X
- Publication type
Article
- DOI
10.3897/rrpharmacology.5.36988