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- Title
Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia.
- Authors
Dahlback, H. S. S.; Gorunova, L.; Micci, F.; Scheie, D.; Brandal, P.; Meling, T. R.; S.Heim
- Abstract
Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7,-10,-13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22). Copyright © 2011 S. Karger AG, Basel
- Subjects
SARCOMA; GLIOMAS; HUMAN cytogenetics; GENOMES; KARYOTYPES; CELL fusion; METAPLASTIC ossification
- Publication
Cytogenetic & Genome Research, 2011, Vol 134, Issue 2, p88
- ISSN
1424-8581
- Publication type
Article
- DOI
10.1159/000326804