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- Title
Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent.
- Authors
Garner, Chad P.; Ding, Yuan C.; John, Esther M.; Ingles, Sue A.; Olopade, Olufunmilayo I.; Dezheng Huo; Adebamowo, Clement; Ogundiran, Temidayo; Neuhausen, Susan L.
- Abstract
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher incidence under age 40 years, are diagnosed with more advanced disease, and have poorer prognosis. We investigated the association of breast cancer and genetic variants in genes in the IGF signaling pathway in a population-based case–control study of African-American women. We found significant associations at a locus encompassing parts of the IGFBP2 and IGFBP5 genes on chromosome 2q35, which we then replicated in a case–control study of Nigerian women. Based on those initial findings, we genotyped a total of 34 single nucleotide polymorphisms (SNPs) across the region in both study populations. Statistically significant associations with breast cancer were observed across approximately 50 kb of DNA sequence encompassing three exons in the 3′ end of IGFBP2 and three exons in the 3′ end of IGFBP5. SNPs were associated with breast cancer risk with P values as low as P = 0.0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk.
- Subjects
HUMAN genetic variation; BIOLOGICAL variation; BREAST cancer; DISEASES in women; GROWTH factors; CANCER
- Publication
Human Genetics, 2008, Vol 123, Issue 3, p247
- ISSN
0340-6717
- Publication type
Article
- DOI
10.1007/s00439-008-0468-x