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- Title
Ginseng modulates the immune response by induction of interleukin-12 production.
- Authors
Larsen, Maria Waldorff; Moser, Claus; Høiby, Niels; Song, Zhijun; Kharazmi, Arsalan
- Abstract
Larsen MW, Moser C, Høiby N, Song Z, Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS 112;2004:369–73.In infections with intracellular microorganisms such as mycobacteria and Leishmania parasites as well as certain extracellular chronic infections such asPseudomonas aeruginosaa Th1 response with activation of macrophages is desirable. Several studies indicate that such a response is associated with better recovery from infection, improved course of the chronic infection, and higher survival rate. In Th1 responses there is increased interferon-γ (IFN-γ) and interleukin-12 (IL-12) production, whereas that of interleukin-10 (IL-10) is decreased. The present study indicated that Ginseng modulation of stimulated peripheral blood mononuclear cells (PBMC) results in a higher IL-12 production. The enhanced IL-12 production could induce a stronger Th1 response, resulting in better protection against infection with a variety of pathogens.
- Subjects
GINSENG; IMMUNE response; INTERLEUKIN-12; INTERFERONS; PATHOGENIC microorganisms
- Publication
APMIS, 2004, Vol 112, Issue 6, p369
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1600-0463.2004.apm1120607.x