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- Title
降钙素基因相关肽、血管活性肠肽在复合应激大鼠模型阴茎组织中表达及伊木萨克干预的研究
- Authors
刘凤霞; 艾孜孜·热合曼; 斯依提·阿木提; 刘文娟; 蒋萍; 阿地力江·伊明
- Abstract
Objective: To detect the expression of CGRP、VIP in the penis tissue of complex stress rats model, and explore the role of Yimusake. Methods: A total of 56 mature male Sprague-Dawley rats were randomly divided into 2 groups: normal control group(N, n= 10) that had normal environment and diet, and model group(n = 46) were treated with spinach and coriander diet in a cold-wet environment for 24 w. Then, the model rats were randomly divided into 3 groups(B1, B2, B3), after treated by Yimusake(250 mg/kg)for 2 weeks, CGRP, VIP were detected by immunohistochemistry(IHC) and Western-blot analysis. Results: ①CGRP expression in rat penis tissue: B1, B2 groups were decreased compared with N group(P<0.05); B3 group was increased compared with B1, B2 group(P<0.05). ②VIP expression in rat penis tissue: B1, B2 groups were decreased compared with N group(P<0.05); B3 group was increased compared with B1, B2 group(P <0.05). Conclusion: CGRP and VIP expression were decreased in the complex stress rats model,Yimusake can promote the CGRP and VIP expression.
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 8, p1446
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.08.010