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- Title
鼠神经生长因子对 2 型糖尿病周围神经病变的影响.
- Authors
陈林江; 张红; 李凯; 李忠; 陈浩然
- Abstract
Objective: To investigate the safety and clinical efficacy of mouse nerve growth factor in treatment of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus. Methods: A total of 89 DPN patients were divided into observation group and control group, with 45 patients in the observation group and 44 patients in the control group. Based on the conventional therapy, the patients in observation group were additionally used mouse nerve growth factor for injection, while the patients in control group were additionally used mecobalamin injection and danhong injection (TCM). The pre- and post- therapeutic sensory conduction velocities (SNCV) and motor nerve conduction velocities (MNCV) of the median nerve and common peroneal nerve, and Toronto clinical scoring system (TCSS) scores were determined. Results: Before the treatment, the patients of the two groups had similar TCSS scores, MNCV and SNCV of median nerve and common peroneal nerve, and the differences were statistically insignificant (P>0.05). At the end of treatment, the TCSS score was decreased in two groups and MNCV and SNCV of median nerve and common peroneal nerve was increased, and the differences were statistically significant (P<0.05), but the observation group had greater improvement extent than that of the control group (P<0.05). For the observation group, the curative effect was excellent in 20 patients, effective in 23 patients, and invalid in 2 patients; while for the control group, the curative effect was excellent in 15 patients, effective in 21 patients, and invalid in 8 patients, and the differences were statistically significant (P<0.05). In the treatment period, no severe adverse reactions occurred in the patients of either group. Conclusions: Additional use of mouse nerve growth factor can effectively relieve the clinical symptoms of DPN and elevate the nerve conductive velocity in patients with type 2 diabetes mellitus with high safety.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 30, p5861
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.30.015