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- Title
Field effect-a New Idea for Early Diagnosis of Prostate Cancer.
- Authors
HAN Gang; YU Ji-yun; CHEN Yu-dong; WANG Qiang; ZHU Jie; WANG Xiao-xiong; ZHANG Xu; YAN Jin-qi; GAO Jiang-ping
- Abstract
To diagnose prostate cancer, many repeat biopsies are needed in patients with prior negative biopsies to prevent missed diagnosis. Though prostate cancer might be detected by repeat biopsies in some patients, many other patients will never be diagnosed with this disease confirmed by long term follow-up and lots of unnecessary biopsies. Recent findings supported histological normal appearing tissue which adjacent to tumor focus, would develop similar molecular changes like cancer. Therefore, we believe that there is a field effect in the procedure of prostate cancerization. By the instruction of this theory, selecting proper marker and detecting its alteration in prostate, clinicians will be able to predict the development of prostate cancer before affirmation of this disease by routine pathological result. It means these patients should be followed closely and carried out more extensive repeat biopsies soon to confirm PCA earlier, while other patients scarcely of this marker in their prostate might possibly be followed less frequently and aggressively. If the confidence of markers reflecting the theory of field effect can be confirmed by further large cohort diagnostic trials, the current situation of prostate cancer diagnosis will be greatly changed.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 9, p1785
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.09.048