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- Title
Aberrant Neurofunctional Responses During Emotional and Attentional Processing Differentiate ADHD Youth With and Without a Family History of Bipolar I Disorder.
- Authors
Patino, L. Rodrigo; Wilson, Allison S.; Tallman, Maxwell J.; Blom, Thomas J.; DelBello, Melissa P.; McNamara, Robert K.
- Abstract
Objective: To compare neurofunctional responses in emotional and attentional networks of psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: ADHD youth with (high-risk, HR, n = 48) and without (low-risk, LR, n = 50) a first-degree relative with BD and healthy controls (n = 46) underwent functional magnetic resonance imaging while performing a continuous performance task with emotional distracters. Region-of-interest analyses were performed for bilateral amygdala (AMY), ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and anterior (ACC) and posterior cingulate cortex (PCC). Results: Compared with HC, HR, but not LR, exhibited predominantly left-lateralized AMY, VLPFC, DLPFC, PCC, and rostral ACC hyperactivation to emotional distractors, whereas LR exhibited right VLPFC and bilateral dorsal ACC hypoactivation to attentional targets. Regional responses correlated with emotional and attention symptoms. Conclusion: Aberrant neurofunctional responses during emotional and attentional processing differentiate ADHD youth with and without a family history of BD and correlate with relevant symptoms ratings.
- Subjects
CONTINUOUS performance test; BIPOLAR disorder; FUNCTIONAL magnetic resonance imaging; FAMILY history (Medicine); CINGULATE cortex
- Publication
Journal of Attention Disorders, 2024, Vol 28, Issue 5, p820
- ISSN
1087-0547
- Publication type
Article
- DOI
10.1177/10870547231215292