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- Title
Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study.
- Authors
Makris N; Seidman LJ; Valera EM; Biederman J; Monuteaux MC; Kennedy DN; Caviness VS Jr; Bush G; Crum K; Brown AB; Faraone SV; Makris, Nikos; Seidman, Larry J; Valera, Eve M; Biederman, Joseph; Monuteaux, Michael C; Kennedy, David N; Caviness, Verne S Jr; Bush, George; Crum, Katherine
- Abstract
<bold>Objective: </bold>We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naïve adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD.<bold>Method: </bold>Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naïve adults with ADHD (n = 13).<bold>Results: </bold>There was a 21% volume reduction in the left ACC of the treatment-naïve group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group.<bold>Conclusion: </bold>These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment.
- Publication
Journal of Attention Disorders, 2010, Vol 13, Issue 4, p407
- ISSN
1087-0547
- Publication type
journal article
- DOI
10.1177/1087054709351671