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- Title
Adoptive immunotherapy for postoperative hepatocellular carcinoma: a systematic review.
- Authors
Zhong, J.-H.; Ma, L.; Wu, L.-C.; Zhao, W.; Yuan, W.-P.; Wu, F.-X.; Zhang, Z.-M.; Huang, S.; You, X. M.; Li, L.-Q.
- Abstract
Summary The high risk of recurrence in post-operative hepatocellular carcinoma (HCC) highlights the need for an effective adjuvant treatment. A systematic review of randomised controlled trials (RCTs) was performed to evaluate the clinical efficacy of adjuvant adoptive immunotherapy (AIT) for post-operative HCC patients. Electronic (MEDLINE, EMBASE and Cochrane Library databases) and manual searches were conducted throughout May 2011 to identify RCTs evaluating postoperative AIT for patients with HCC. Methodological quality was assessed in accordance with the QUOROM statement. Four RCTs totalling 423 patients met the eligibility criteria. All RCTs reported significantly improved disease-free survival rate or reduced recurrence rate after treating with adjuvant AIT (p < 0.05). The overall survival rates of AIT group are slightly higher than those of the control group in one study. Moreover, AIT was a safe treatment, with fever as the main adverse effects. This study adds to the evidence that postoperative HCC patients treated with adjuvant AIT show an improvement in disease-free survival rate or recurrence rate.
- Publication
International Journal of Clinical Practice, 2012, Vol 66, Issue 1, p21
- ISSN
1368-5031
- Publication type
Article
- DOI
10.1111/j.1742-1241.2011.02814.x