We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Enoxaparin Increases D6 Receptor Expression and Restores Cytoskeleton Organization in Trophoblast Cells from Preeclampsia.
- Authors
Tersigni, Chiara; Maulucci, Giuseppe; Castellani, Roberta; Bianchetti, Giada; Onori, Marianna; Franco, Rita; Barbaro, Greta; De Spirito, Marco; Lanzone, Antonio; Scambia, Giovanni; Di Simone, Nicoletta
- Abstract
D6 is a scavenger receptor for CC chemokines expressed in the human placenta. It prevents excessive leukocyte tissue infiltration by internalizing chemokines through cytoskeleton-dependent intracellular transport. In preeclampsia (PE), the D6 receptor is overexpressed in trophoblast cells, but functionally impaired, due to cytoskeleton destructuring. Low molecular weight heparin (LMWH) represents a potential treatment for PE based on its anti-thrombotic and anti-inflammatory properties. Here, we investigated the effect of enoxaparin on D6 expression, and cytoskeleton organization primary cytotrophoblast cell cultures were obtained from the placentae of women with PE (n = 9) or uncomplicated pregnancy (n = 9). We demonstrated that enoxaparin is able to (i) increase D6 expression, and (ii) improve cytoskeletal fiber alignment in trophoblast cells from PE patients.
- Subjects
TROPHOBLAST; LOW-molecular-weight heparin; ENOXAPARIN; CYTOSKELETON; PREECLAMPSIA
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 13, pN.PAG
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11132036