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- Title
Cell-Free DNA in Oncology: Gearing up for Clinic.
- Authors
Ulrich, Bryan C.; Paweletz, Cloud P.
- Abstract
In the past several years, interest in the clinical utility of cell-free DNA as a noninvasive cancer biomarker has grown rapidly. Success in the development of plasma genotyping assays and other liquid biopsy assays has widened the scope of cell-free DNA use in research and the clinic. Already approved by the US Food and Drug Administration in the narrow context of epidermal growth factor receptor-mutated non-small cell lung cancer, plasma genotyping assays are currently being investigated in a wide array of clinical settings and modalities. These include plasma genotyping as a tool for early diagnosis, the detection of minimal residual disease, and the evaluation of treatment response/progression. In this review, we assess the clinical landscape of plasma genotyping assays and propose strategies for their further expansion into routine clinical care.
- Subjects
CIRCULATING tumor DNA; TUMOR markers; BIOLOGICAL assay; NON-small-cell lung carcinoma; EARLY diagnosis
- Publication
Annals of Laboratory Medicine, 2018, Vol 38, Issue 1, p1
- ISSN
2234-3806
- Publication type
Article
- DOI
10.3343/alm.2018.38.1.1