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- Title
Genomic and in vitro pharmacodynamic analysis of rifampicin resistance in multidrug‐resistant canine Staphylococcus pseudintermedius isolates.
- Authors
Hicks, Karly; Tan, Yongjun; Cao, Wenqi; Hathcock, Terri; Boothe, Dawn; Kennis, Robert; Zhang, Dapeng; Wang, Xu; White, Amelia
- Abstract
B Hypothesis/Objectives - b To determine an optimal RFP dosing for MDR-MRSP treatment without induction of RFP resistance and identify causal mutations for antimicrobial resistance. Despite this, veterinarians are using this drug as monotherapy for the treatment of canine MRSP pyoderma with success,18,19 although RFP resistance developed in six of 11 dogs in one study.18 Dogs that received RFP in combination therapy also were reported to develop RFP resistance.17 Systematic studies of RFP pharmacokinetics are in urgent need to determine the optimal dose to prevent AMR development. Genomic and in vitro pharmacodynamic analysis of rifampicin resistance in multidrug-resistant canine Staphylococcus pseudintermedius isolates Keywords: rifampicin; multidrug resistance; Staphylococcus pseudintermedius; canine; antimicrobial resistance; pyoderma; dermatitis EN rifampicin multidrug resistance Staphylococcus pseudintermedius canine antimicrobial resistance pyoderma dermatitis 219 219 1 05/22/21 20210601 NES 210601 B Background - b Antimicrobial resistance is a growing concern in canine I Staphylococcus pseudintermedius i dermatitis.
- Subjects
BETA lactam antibiotics; STAPHYLOCOCCUS; RIFAMPIN; MUPIROCIN; METHICILLIN-resistant staphylococcus aureus; HORIZONTAL gene transfer; NUCLEOTIDE sequencing
- Publication
Veterinary Dermatology, 2021, Vol 32, Issue 3, p219
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/vde.12959