We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Unusual Talaromyces marneffei and Pneumocystis jirovecii coinfection in a child with a STAT1 mutation: A case report and literature review.
- Authors
Qin Yang; Chendi Yu; Yue Wu; Ke Cao; Xiaonan Li; Weiguo Cao; Lichao Cao; Shenrui Zhang; Ying Ba; Yuejie Zheng; Hezi Zhang; Wenjian Wang
- Abstract
Talaromyces marneffei and Pneumocystis jirovecii are the common opportunistic pathogens in immunodeficient patients. There have been no reports of T. marneffei and P. jirovecii coinfection in immunodeficient children. Signal transducer and activator of transcription 1 (STAT1) is a key transcription factor in immune responses. STAT1 mutations are predominately associated with chronic mucocutaneous candidiasis and invasive mycosis. We report a 1-year-2-month-old boy diagnosed with severe laryngitis and pneumonia caused by T. marneffei and P. jirovecii coinfection, which was confirmed by smear, culture, polymerase chain reaction and metagenome next-generation sequencing of bronchoalveolar lavage fluid. He has a known STAT1 mutation at amino acid 274 in the coiled-coil domain of STAT1 according to whole exome sequencing. Based on the pathogen results, itraconazole and trimethoprimsulfamethoxazole were administered. This patient's condition improved, and he was discharged after two weeks of targeted therapy. In the one-year followup, the boy remained symptom-free without recurrence.
- Subjects
STAT proteins; MIXED infections; INVASIVE candidiasis; TALAROMYCES; LITERATURE reviews; PNEUMOCYSTIS jiroveci; PULMONARY eosinophilia
- Publication
Frontiers in Immunology, 2023, Vol 14, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1103184