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- Title
Safety and immunogenicity of 3 doses of BNT162b2 and CoronaVac in children and adults with inborn errors of immunity.
- Authors
Daniel Leung; Xiaofeng Mu; Duque, Jaime S. Rosa; Cheng, Samuel M. S.; Manni Wang; Wenyue Zhang; Yanmei Zhang; Tam, Issan Y. S.; Lee, Toby S. S.; Lam, Jennifer H. Y.; Sau Man Chan; Cheuk Hei Cheang; Yuet Chung; Wong, Howard H. W.; Lee, Amos M. T.; Wing Yan Li; Chaothai, Sara; Tsang, Leo C. H.; Chua, Gilbert T.; Kai-Ning Cheong
- Abstract
Our study (NCT04800133) aimed to determine the safety and immunogenicity in patients with IEIs receiving a 3-dose primary series of mRNA vaccine BNT162b2 (age 12+) or inactivated whole-virion vaccine CoronaVac (age 3+) in Hong Kong, including Omicron BA.1 neutralization, in a nonrandomized manner. Intradermal vaccination was also studied. Thirty-nine patients were vaccinated, including 16 with homologous intramuscular 0.3ml BNT162b2 and 17 with homologous intramuscular 0.5ml CoronaVac. Two patients received 3 doses of intradermal 0.5ml CoronaVac, and 4 patients received 2 doses of intramuscular BNT162b2 and the third dose with intradermal BNT162b2. No safety concerns were identified. Inadequate S-RBD IgG and surrogate virus neutralization responses were found after 2 doses in patients with humoral immunodeficiencies and especially so against BA.1. Dose 3 of either vaccine increased S-RBD IgG response. T cell responses against SARS-CoV-2 antigens were detected in vaccinated IEI patients by intracellular cytokine staining on flow cytometry. Intradermal third dose vaccine led to high antibody response in 4 patients. The primary vaccination series of BNT162b2 and CoronaVac in adults and children with IEIs should include 3 doses for optimal immunogenicity.
- Subjects
HONG Kong (China); COVID-19 vaccines; IMMUNE response; IMMUNITY; ANTIBODY formation; SARS-CoV-2 Omicron variant
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.982155