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- Title
Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys.
- Authors
Soni, Priya Y.; Wang, Yumin; Eckert, George J.; Ismail, Heba M.
- Abstract
Aim: To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset. Research Design and Methods: In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES dataset for participants aged 12 to <18 years (n = 2063). Results: The mean ± SE age of the participants was 14.99 ± 0.06 years. The participants included 992 girls and 1071 boys, and more than 80% of participants had a body mass index (BMI) percentile of <85%. Among boys, the most notable finding was the increase in geometric mean C‐peptide level from 0.51 nmol/L at age 12, to 0.65 nmol/L at age 15 years. Among girls, levels fluctuated around a geometric mean of 0.67 nmol/L. Girls had significantly higher mean log‐transformed C‐peptide concentrations than boys (P < 0.0001) after adjusting for age, race and BMI percentile category. After adjusting for age and BMI percentile category, non‐Hispanic Black boys and girls had significantly lower C‐peptide levels than non‐Hispanic White (P = 0.0026 and P = 0.0093) and Mexican American boys and girls (P < 0.0001 and P < 0.0001), respectively. Despite these findings, both insulin and homeostatic model assessment of insulin resistance were greater in non‐Hispanic Black compared to non‐Hispanic White participants. Conclusions: Here we describe fasting C‐peptide levels in a non‐diabetic adolescent population. These data provide crucial insight into evaluating racial differences in endogenous insulin release and clearance and will provide novel information which can be used in assessing residual β‐cell function and response to intervention therapy.
- Subjects
HEALTH &; Nutrition Examination Survey; FASTING; C-peptide; ADOLESCENT health
- Publication
Diabetes, Obesity & Metabolism, 2022, Vol 24, Issue 3, p539
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.14611