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- Title
Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study.
- Authors
Haeyoung Kim; Won Park; Jeong Il Yu; Doo Ho Choi; Seung Jae Huh; Yeon-Joo Kim; Eun Sook Lee; Keun Seok Lee; Han-Sung Kang; In Hae Park; Kyung Hwan Shin; Chan Woo Wee; Kyubo Kim; Kyung Ran Park; Yong Bae Kim; Sung Ja Ahn; Jong Hoon Lee; Jin Hee Kim; Mison Chun; Hyung-Sik Lee
- Abstract
Purpose This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and Methods We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups. Results A total of 41 patients (7.6%) were found to have recurrence. Supraclavicular lymph node (SCN) failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% versus 92.6% (p=0.50) and 95.1% versus 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI. Conclusion We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy.
- Subjects
BREAST cancer patients; PROGNOSTIC tests; LUMPECTOMY; ANTHRACYCLINES; CANCER chemotherapy
- Publication
Cancer Research & Treatment, 2017, Vol 49, Issue 4, p970
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2016.382